Selected Publications

  1. Fisher, P.R., Smith, E. and Williams, K.L. (1981). An extracellular chemical signal controlling phototactic behaviour by D. discoideum slugs. Cell 23, 799-807.

  2. Fisher, P.R. and Williams, K.L. (1982). Thermotactic behaviour by Dictyostelium discoideum slug phototaxis mutants. J. Gen. Microbiol. 128, 965-971.

  3. Fisher, P.R., Dohrmann, U. and Williams, K.L. (1984). Signal processing in Dictyostelium discoideum slugs. Modern Cell Biol. 3, 197-248.

  4. Darcy, P.K. and Fisher, P.R. (1989). A role for G-proteins and inositol phosphate signalling in Dictyostelium discoideum slug behaviour. J. Gen. Microbiol. 135, 1909-1915.

  5. Darcy, P.K. and Fisher, P.R. (1990). Pharmacological evidence for a role for cAMP signalling in Dictyostelium discoideum slug behaviour. J. Cell Sci. 96, 661-667.

  6. Fisher, P.R., Karampetsos, P.D., Wilczynska, Z. and Rosenberg, L.T. (1991). Oxidative metabolism and heat shock enhanced chemiluminescence in Dictyostelium discoideum. J. Cell Sci. 99, 741-750.

  7. Darcy, P.K., Wilczynska, Z. and Fisher, P.R. (1994). The role of cGMP in photosensory and thermosensory transduction in Dictyostelium discoideum. Microbiol. 140, 1619-1632.

  8. Darcy, P.K., Wilczynska, Z. and Fisher, P.R. (1994). Genetic analysis of Dictyostelium slug phototaxis mutants. Genetics 137, 977-985.

  9. Wilczynska, Z. and Fisher, P.R. (1994). Analysis of a complex plasmid insertion in a phototaxis-deficient transformant of Dictyostelium discoideum selected on a Micrococcus luteus lawn. Plasmid 32, 182-194.

  10. Barth, C., Wilczynska, Z., Pontes, L., Fraser, D.J. and Fisher, P.R. (1996). Efficient circularization in Escherichia coli of linear plasmid multimers from Dictyostelium discoideum genomic DNA. Plasmid 36, 86-94.

  11. McMahon, T.L., Wilczynska, Z., Barth, C., Fraser, D.J., Pontes, L. and Fisher, P.R. (1996). Replicon rescue: a novel strategy to clone the genomic DNA flanking insertions of integrating shuttle vector DNA. Nucleic Acids Research 24, 4096-4097.

  12. Schaap, P., Nebl, T. and Fisher, P.R. (1996). A slow sustained increase in cytosolic Ca2+ levels mediates stalk gene induction by differentiation inducing factor in Dictyostelium. EMBO J. 15, 5177-5183.

  13. Fisher, P.R. (1997). Genetics of phototaxis in a model eukaryote, Dictyostelium discoideum. Bioessays 19, 397-408.

  14. Wilczynska, Z., Barth, C. and Fisher, P.R. (1997). Mitochondrial mutations impair signal transduction in Dictyostelium discoideum slugs. Biochem. Biophys. Res. Comm. 234, 39-43.

  15. Nebl, T. and Fisher, P. R. (1997). Intracellular Ca2+ signals in Dictyostelium chemotaxis are mediated exclusively by Ca2+ influx. Journal of Cell Science 110, 2845-2853. (Full text pdf file at J. Cell Science online.)

  16. Fisher, P.R., Noegel, A.A., Fechheimer, M., Rivero, F., Prassler, J. and Gerisch, G. (1997). Photosensory and thermosensory responses in Dictyostelium slugs are specifically impaired by absence of the F-actin cross-linking gelation factor (ABP-120). Current Biology 7, 889-892.

  17. Barth, C., Fraser, D.J. and Fisher, P.R. (1998). Co-insertional replication is responsible for tandem multiple formation during plasmid integration into the Dictyostelium genome. Plasmid 39, 141-153.

  18. Barth, C., Fraser, D.J. and Fisher, P.R. (1998). A rapid, small scale method for characterization of plasmid insertions in the Dictyostelium genome. Nucleic Acids Research 26, 3317-3318.

  19. Barth, C., Greferath, U., Kotsifas, M. and Fisher, P.R. (1999). Polycistronic transcription and editing of the mitochondrial small subunit (SSU) ribosomal RNA in Dictyostelium discoideum. Current Genetics 36, 55-61.
    Full text pdf file at Current Genetics on line.

  20. Schenk, P.W., Nebl, T., Fisher, P.R. and Snaar-Jagalska, B.E. (1999). A serpentine receptor-dependent, Gb- and Ca2+ influx-independent pathway regulates mitogen-activated protein kinase ERK2 in Dictyostelium. Biochem. Biophys. Res. Comm. 260, 504-509.

  21. Wilkins, A., Khosla, M., Fraser, D.J., Spiegelman, G.B., Fisher, P.R., Weeks, G. and Insall, R.H. (2000). Dictyostelium RasD is required for normal phototaxis, but not differentiation or pattern formation. Genes & Development 14, 1407-1413. (Full text pdf file at Genes & Development on line.)

  22. Fisher, P.R. (2001). Genetic analysis of phototaxis in Dictyostelium. Chapter 19 in Photomovement. ESP Comprehensive Series in Photosciences Vol 1.pp. 519-559. Edited by D-P. Hader & M. Lebert. Elsevier Science Ltd. Amsterdam.
    Preprint version pdf file made available with permission from Elsevier Science Ltd.

  23. Barth C., Greferath U., Kotsifas M., Tanaka Y., Alexander S., Alexander H. and Fisher P.R. (2001). Transcript mapping and processing of mitochondrial RNA in Dictyostelium discoideum. Current Genetics 39, 355-364. First published On Line 21, June 2001. DOI 10.1007/s002940100196. (Full text pdf file at Current Genetics.)

  24. Fisher, P.R. (2002). Phototaxis: Microbial. In Encyclopedia of Life Sciences. Nature Publishing Group. London.

  25. Kotsifas, M., Barth, C., Lay, S.T., de Lozanne, A. & Fisher, P.R. (2002). Chaperonin 60 and mitochondrial disease in Dictyostelium. J. Muscle Research and Cell Motility. 23, 839-852.

  26. Nebl, T., Kotsifas, M., Schaap, P. & Fisher, P.R. (2002). Multiple pathways connect chemoattractant receptors and Ca2+ channels in Dictyostelium. J. Muscle Research and Cell Motility. 23, 853-865.

  27. Gilson, P.R., Yu, X-C., Hereld, D, Bareth, C., Savage, A., Kiefel, B., Lay, S., Fisher, P.R., Margolin, W., & Beech, P.L. (2003). Two Dictyostelium orthologs of the prokaryotic cell division protein, FtsZ, localize to mitochondria and are required for the maintenance of normal mitochondrial morphology. Eukaryotic Cell 2, 1315-1326. (Full text pdf file.)

  28. Wilkins, A., Szafranski, K., Fraser, D.J., Bakthavatsalam, D., Muller, R., Fisher, P.R., Glockner, G., Eichinger, L., Noegel, A. & Insall, R.H. (2005). The Dicytostelium genome encodes numerous RasGEFS with multiple biological roles. BMC Genome Biology 6, R68.

  29. Fisher, P.R. (2005). Microbial development. In Encyclopedia of Molecular Cell Biology and Molecular Medicine Vol. 8. pp 289-342. Ed. R.A. Meyers. Wiley-VCH, Weinheim.
    Prepint version pdf file.

  30. Wilczynska, Z., Happle, K., Muller-Taubenberger, A., Schlatterer, C., Malchow, D. & Fisher, P.R. (2005). Release of Ca2+ from the endoplasmic reticulum contributes to Ca2+ signaling in Dictyostelium. Eukaryotic Cell. 4, 1513-1525.

  31. Fisher, P.R. & Annesley, S.J. (2006). Slug phototaxis, thermotaxis and spontaneous turning behaviour. In "Dictyostelium discoideum Protocols." Methods in Molecular Biology. 346, 137-170. Ed. L Eichinger & F. Rivero. Humana Press.
    Accompanying directional statistics package for use in the R environment for statistical computing - DirStats

  32. Fisher, P.R. & Wilczynska, Z. (2006). The ER contribution to cytosolic Ca2+ signals in Dictyostelium depends upon extracellular Ca2+. FEMS Letters 257, 268-277.

  33. Ahmed A.U., Beech, P.L., Lay, S.T., Gilson, P.R. & Fisher, P.R. (2006). Import-associated translational inhibition - novel in vivo evidence for cotranslational protein import into Dictyostelium mitochondria. Eukaryotic Cell 5, 1314-1327.

  34. Bandala-Sanchez, E., Annesley, S.J. and Fisher, P.R. (2006). A phototaxis signalling complex in Dictyostelium discoideum. European Journal of Cell Biology. 85, 1099-1106.

  35. Bokko, P.B., Francione, L., Bandala-Sanchez, E., Ahmed, A.U., Annesley, S.J., Huang, X., Khurana, T., Kimmel, A.R. & Fisher, P.R. (2007). Diverse Cytopathologies in Mitochondrial Disease Are Caused by AMPK Signalling Molecular Biology of the Cell 18, 1874-1886. Published March 1, 2007 as 10.1091/mbc.E06-09-0881 (Copyright American Society for Cell Biology).
    Supplemental videos. Copyright American Society for Cell Biology.

  36. Barth, C., Le, P. & Fisher, P.R. (2007). Mitochondrial biology and disease in Dictyostelium. Int. Rev. Cytology 263, 207-252.

  37. Annesley, S.J.,  Bandala-Sanchez, E., Ahmed, A.U. & Fisher, P.R. (2007).Filamin repeat segments required for photosensory signalling in Dictyostelium discoideum. BMC Cell Biology 8, 48

  38. Ludlow, M.J., Traynor, D., Fisher, P.R. & Ennion, S.J. (2008). Purinergic-mediated Ca2+ influx in Dictyostelium discoideum. Cell Calcium. 44, 567-579.

  39. Francione, L., Smith, P.K., Accari, S.L., Taylor, P.E., Bokko, P.B., Bozzarro, S., Beech, P.L. & Fisher, P.R. (2009).Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells. Disease Models and Mechanisms 2, 479-489.
    Published on line before print, July 28, 2009, DOI: 10.1242/dmm.003319

  40. Ahmed, A.U. & Fisher, P.R. (2009). Import of nuclear-encoded mitochondrial proteins: a cotranslational perspective. International Review of Cell and Molecular Biology 273, 49-68.

  41. Annesley, S.J. & Fisher, P.R. (2009). Dictyostelium discoideum – a model for many reasons. Mol. Cell. Biochem. 329, 73-91.
    Published Online 22 April 2009. DOI: 10.1007/s11010-009-0111-8.

  42. Le, P., Fisher, P.R. & Barth, C. (2009). Transcription of the Dictyostelium genome occurs from a single initiation site. RNA 15, 2321-2330.

  43. Francione, L. & Fisher, P.R. (2010). Cytopathological Mechanisms in Mitochondrial Disease. Current Chemical Biology 4, 32-48. Bentham Science Publishers.
    Preprint pdf file.

  44. Carilla-Latorre, S., Gallardo, M.E., Annesley, S.J. Calvo-Garrido, J., Graña, O., Accari, S.L., Smith, P.K., Valencia, A., Garesse, R., Fisher, P.R. & Escalante, R. (2010). MidA is a putative mitochondrial methyltransferase required for mitochondrial complex I function. J. Cell Sci. 123, 1674-1683.

  45. Francione, L.M., Annesley, S.J., Carilla-Latorre, S., Escalante, R. & Fisher, P.R. (2011) The Dictyostelium model for mitochondrial disease. Seminars in Cell and Developmental Biology. 22, 120-130.
    Preprint pdf file.

  46. Kicak, S., Shen, Z.X., Annesley, S.J., Fisher, P.R., Lee, S., Briggs, S. & Firtel, R.A. (2011). The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton. Molecular Biology of the Cell. 22, 2198-2211.

  47. Annesley, S.J., Bago, R., Mehta, A. and Fisher, P.R. (2011) A genetic interaction between NDPK and AMPK in Dictyostelium discoideum that affects motility, growth and development. Naunyn-Schmiedeberg Archives of Pharmacology. 384, 341-349.
    Preprint pdf file.

  48. Francione, L.M. and Fisher, P.R. (2011) Heteroplasmic mitochondrial disease in Dictyostelium discoideum. Biochem. Pharmacol. 82, 1510-1520.
    Preprint pdf file.

  49. Annesley, S.J., Bago, R., Bosnar, M.H., Filic, V., Marinović, M., Weber, I., Mehta, A. & Fisher, P.R. (2011). Dictyostelium discoideum nucleoside diphosphate kinase C plays a negative regulatory role in phagocytosis, macropinocytosis and exocytosis. PLoS ONE 6, e26024.

  50. Allan, C.Y. & Fisher, P.R. (2011). Phototaxis: Microbial. In eLS 2011, John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0000399.pub2.

  51. Ilievska, J., Bishop, N.E., Annesley, S.J. &Fisher, P.R. (2012). The roles of ESCRT proteins in healthy cells and in disease. Chapter 20 in “Current Frontiers and Perspectives in Cell Biology”. Ed. by Stevo Najman. ISBN 978-953-51-0544-2. InTech, Croatia.
    Preprint pdf file.

  52. Aziz, A.,Ilievska, J., Fisher, P.R. & Bishop, N.E. (2012) An evolutionary biology approach to understanding neurological disorders. Chapter 1 in “Protein Structure”. ISBN 978-953-51-0555-8. InTech, Croatia.
    Preprint pdf file.

  53. Last updated 26 August 2012

Experimental Protocols

  1. Plasmid DNA Preparation and Purification using Celite Resin

  2. A rapid, small scale method for characterization of plasmid insertions in the Dictyostelium genome. (Full text pdf reproduced with permission from NAR Online.)

Last updated 26 August 2012

Student Notes

Posted by Paul Fisher

  1. MIC2IM/AGR3ANH Microbial Diversity Notes

  2. Long Study Questions

  3. Short Study Questions

Last updated 26 August 2012